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Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin
R-spondin proteins sensitize cells to Wnt signalling and act as potent stem cell growth factors. Various membrane proteins have been proposed as potential receptors of R-spondin, including LGR4/5, membrane E3 ubiquitin ligases ZNRF3/RNF43 and several others proteins. Here, we show that R-spondin int...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
European Molecular Biology Organization
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3981092/ https://ncbi.nlm.nih.gov/pubmed/24165923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.167 |
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