Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin

R-spondin proteins sensitize cells to Wnt signalling and act as potent stem cell growth factors. Various membrane proteins have been proposed as potential receptors of R-spondin, including LGR4/5, membrane E3 ubiquitin ligases ZNRF3/RNF43 and several others proteins. Here, we show that R-spondin int...

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Hlavní autoři: Xie, Yang, Zamponi, Raffaella, Charlat, Olga, Ramones, Melissa, Swalley, Susanne, Jiang, Xiaomo, Rivera, Daniel, Tschantz, William, Lu, Bo, Quinn, Lisa, Dimitri, Chris, Parker, Jefferson, Jeffery, Doug, Wilcox, Sheri K, Watrobka, Mike, LeMotte, Peter, Granda, Brian, Porter, Jeffrey A, Myer, Vic E, Loew, Andreas, Cong, Feng
Médium: Artigo
Jazyk:Inglês
Vydáno: European Molecular Biology Organization 2013
Témata:
Scientific Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3981092/
https://ncbi.nlm.nih.gov/pubmed/24165923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.167
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