Structural basis for R-spondin recognition by LGR4/5/6 receptors

The R-spondin (RSPO) family of secreted proteins (RSPO1–RSPO4) has pleiotropic functions in development and stem cell growth by strongly enhancing Wnt pathway activation. Recently, leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4), LGR5, and LGR6 have been identified as receptors fo...

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Detalhes bibliográficos
Main Authors: Wang, Dongli, Huang, Binlu, Zhang, Senyan, Yu, Xiaojuan, Wu, Wei, Wang, Xinquan
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701189/
https://ncbi.nlm.nih.gov/pubmed/23756652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.219360.113
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