Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability

Neuronal atrophy in neurodegenerative diseases is commonly viewed as an early event in a continuum that ultimately results in neuronal loss. In a mouse model of the polyglutamine disorder spinocerebellar ataxia type 1 (SCA1), we tested the hypothesis that cerebellar Purkinje neuron atrophy serves an...

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Опубликовано в: :J Neurosci
Главные авторы: Dell'Orco, James M., Wasserman, Aaron H., Chopra, Ravi, Ingram, Melissa A. C., Hu, Yuan-Shih, Singh, Vikrant, Wulff, Heike, Opal, Puneet, Orr, Harry T., Shakkottai, Vikram G.
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532759/
https://ncbi.nlm.nih.gov/pubmed/26269637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1357-15.2015
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