Targeting potassium channels to treat cerebellar ataxia

OBJECTIVE: Purkinje neuron dysfunction is associated with cerebellar ataxia. In a mouse model of spinocerebellar ataxia type 1 (SCA1), reduced potassium channel function contributes to altered membrane excitability resulting in impaired Purkinje neuron spiking. We sought to determine the relationshi...

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Dettagli Bibliografici
Pubblicato in:Ann Clin Transl Neurol
Autori principali: Bushart, David D., Chopra, Ravi, Singh, Vikrant, Murphy, Geoffrey G., Wulff, Heike, Shakkottai, Vikram G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846455/
https://ncbi.nlm.nih.gov/pubmed/29560375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.527
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