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Early Changes in Cerebellar Physiology Accompany Motor Dysfunction in the Polyglutamine Disease Spinocerebellar Ataxia Type 3

The relationship between cerebellar dysfunction, motor symptoms, and neuronal loss in the inherited ataxias, including the polyglutamine disease spinocerebellar ataxia type 3 (SCA3), remains poorly understood. We demonstrate that before neurodegeneration, Purkinje neurons in a mouse model of SCA3 ex...

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主要な著者: Shakkottai, Vikram G., do Carmo Costa, Maria, Dell'Orco, James M., Sankaranarayanan, Ananthakrishnan, Wulff, Heike, Paulson, Henry L.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170039/
https://ncbi.nlm.nih.gov/pubmed/21900579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2789-11.2011
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