BH3-mimetic small molecule inhibits the growth and recurrence of adenoid cystic carcinoma

OBJECTIVES: To evaluate the anti-tumor effect of BM-1197, a new potent and highly specific small molecule inhibitor of Bcl-2/Bcl-x(L), in preclinical models of human adenoid cystic carcinoma (ACC). METHODS: Low passage primary human adenoid cystic carcinoma cells (UM-HACC-2A,-2B,-5,-6) and patient-d...

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Publicado en:Oral Oncol
Autores principales: Acasigua, Gerson A., Warner, Kristy A., Nör, Felipe, Helman, Joseph, Pearson, Alexander T., Fossati, Anna C., Wang, Shaomeng, Nör, Jacques E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532618/
https://ncbi.nlm.nih.gov/pubmed/26121939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.oraloncology.2015.06.004
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