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Catalytic Asymmetric Hydroamination of Unactivated Internal Olefins to Aliphatic Amines

Catalytic assembly of enantiopure aliphatic amines from abundant and readily available precursors has long been recognized as a paramount challenge in synthetic chemistry. Herein, we describe a mild and general copper-catalyzed hydroamination that effectively converts unactivated internal olefins, a...

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Détails bibliographiques
Publié dans:Science
Auteurs principaux: Yang, Yang, Shi, Shi-Liang, Niu, Dawen, Liu, Peng, Buchwald, Stephen L.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532314/
https://ncbi.nlm.nih.gov/pubmed/26138973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aab3753
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