The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and the burden of age-related chronic diseases. Here, we describe the rationale for identification and validation...

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Publicat a:Aging Cell
Autors principals: Zhu, Yi, Tchkonia, Tamara, Pirtskhalava, Tamar, Gower, Adam C, Ding, Husheng, Giorgadze, Nino, Palmer, Allyson K, Ikeno, Yuji, Hubbard, Gene B, Lenburg, Marc, O’Hara, Steven P, LaRusso, Nicholas F, Miller, Jordan D, Roos, Carolyn M, Verzosa, Grace C, LeBrasseur, Nathan K, Wren, Jonathan D, Farr, Joshua N, Khosla, Sundeep, Stout, Michael B, McGowan, Sara J, Fuhrmann-Stroissnigg, Heike, Gurkar, Aditi U, Zhao, Jing, Colangelo, Debora, Dorronsoro, Akaitz, Ling, Yuan Yuan, Barghouthy, Amira S, Navarro, Diana C, Sano, Tokio, Robbins, Paul D, Niedernhofer, Laura J, Kirkland, James L
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2015
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4531078/
https://ncbi.nlm.nih.gov/pubmed/25754370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12344
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