Towards a transgenic mouse model of sickle cell disease: hemoglobin SAD.

In order to obtain a transgenic mouse model of sickle cell disease, we have synthesized a novel human beta-globin gene, beta SAD, designed to increase the polymerization of the transgenic human hemoglobin S (Hb S) in vivo. beta SAD (beta S-Antilles-D Punjab) includes the beta 6Val substitution of th...

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Udgivet i:	EMBO J
Principais autores:	Trudel, M, Saadane, N, Garel, M C, Bardakdjian-Michau, J, Blouquit, Y, Guerquin-Kern, J L, Rouyer-Fessard, P, Vidaud, D, Pachnis, A, Roméo, P H
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 1991
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC453038/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1915288/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1991.tb04877.x
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