Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives.

Eitemau Tebyg

• Treatment with oral clotrimazole blocks Ca(2+)-activated K+ transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease.
  gan: De Franceschi, L, et al.
  Cyhoeddwyd: (1994)
• Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease.
  gan: Brugnara, C, et al.
  Cyhoeddwyd: (1996)
• Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease.
  gan: De Franceschi, L, et al.
  Cyhoeddwyd: (1997)
• Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice
  gan: Rust, Marco B., et al.
  Cyhoeddwyd: (2007)
• Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease.
  gan: Shmukler, Boris E., et al.
  Cyhoeddwyd: (2019)