Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives.

We have investigated the interaction of clotrimazole (CLT) and related compounds with the erythroid Ca(2+)-activated K+ channel, a mediator of sickle cell dehydration. We measured K+ transport, membrane potential, and cell volume upon activation of this pathway in sickle erythrocytes. CLT blocked al...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Brugnara, C, de Franceschi, L, Alper, S L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC293641/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8326017/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116597
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