The novel metabotropic glutamate receptor 2 positive allosteric modulator, AZD8529, decreases nicotine self-administration and relapse in squirrel monkeys

BACKGROUND: Based on rodent studies, Group II metabotropic glutamate receptors (mGluR2 & 3) were suggested as targets for addiction treatment. However, LY379268 and other Group II agonists do not discriminate between the mainly presynaptic inhibitory mGluR2 (the proposed treatment target) and mG...

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Publicat a:Biol Psychiatry
Autors principals: Justinova, Zuzana, Panlilio, Leigh V., Secci, Maria E., Redhi, Godfrey H., Schindler, Charles W., Cross, Alan J., Mrzljak, Ladislav, Medd, Amy, Shaham, Yavin, Goldberg, Steven R.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529372/
https://ncbi.nlm.nih.gov/pubmed/25802079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2015.01.014
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