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Structure of human Roquin-2 and its complex with constitutive-decay element RNA

Roquin mediates mRNA degradation by recognizing the constitutive-decay element (CDE) in the 3′ untranslated region of the target gene followed by recruitment of the deadenylation machinery. Deficiency or dysfunction of Roquin has been associated with autoimmunity and inflammation. To establish the s...

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Pubblicato in:Acta Crystallogr F Struct Biol Commun
Autori principali: Sakurai, Shunya, Ohto, Umeharu, Shimizu, Toshiyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Union of Crystallography 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528940/
https://ncbi.nlm.nih.gov/pubmed/26249698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X15011887
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