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Structure of human Roquin-2 and its complex with constitutive-decay element RNA

Roquin mediates mRNA degradation by recognizing the constitutive-decay element (CDE) in the 3′ untranslated region of the target gene followed by recruitment of the deadenylation machinery. Deficiency or dysfunction of Roquin has been associated with autoimmunity and inflammation. To establish the s...

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Detalhes bibliográficos
Publicado no:Acta Crystallogr F Struct Biol Commun
Main Authors: Sakurai, Shunya, Ohto, Umeharu, Shimizu, Toshiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528940/
https://ncbi.nlm.nih.gov/pubmed/26249698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X15011887
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