Chargement en cours...
Hypomorphic MGAT5 polymorphisms promote multiple sclerosis cooperatively with MGAT1 and interleukin-2 and 7 receptor variants
Deficiency of the Golgi N-glycan branching enzyme Mgat5 in mice promotes T cell hyperactivity, endocytosis of CTLA-4 and autoimmunity, including a spontaneous multiple sclerosis (MS)-like disease. Multiple genetic and environmental MS risk factors lower N-glycan branching in T cells. These include v...
Enregistré dans:
| Publié dans: | J Neuroimmunol |
|---|---|
| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4528623/ https://ncbi.nlm.nih.gov/pubmed/23351704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2012.12.008 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|