Hypomorphic MGAT5 polymorphisms promote multiple sclerosis cooperatively with MGAT1 and interleukin-2 and 7 receptor variants

Deficiency of the Golgi N-glycan branching enzyme Mgat5 in mice promotes T cell hyperactivity, endocytosis of CTLA-4 and autoimmunity, including a spontaneous multiple sclerosis (MS)-like disease. Multiple genetic and environmental MS risk factors lower N-glycan branching in T cells. These include v...

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Detaylı Bibliyografya
Yayımlandı:J Neuroimmunol
Asıl Yazarlar: Li, Carey F., Zhou, Raymond W., Mkhikian, Haik, Newton, Barbara L., Yu, Zhaoxia, Demetriou, Michael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528623/
https://ncbi.nlm.nih.gov/pubmed/23351704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2012.12.008
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