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Family studies of Type 1 diabetes reveal additive and epistatic effects between MGAT1 and three other polymorphisms
In a recent study of Multiple Sclerosis (MS), we observed additive effects and epistatic interactions between variants of four genes that converge to induce T cell hyper-activity by altering Asn-(N) linked protein glycosylation: namely, the Golgi enzyme MGAT1, cytotoxic T-lymphocyte antigen 4 (CTLA-...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4047175/ https://ncbi.nlm.nih.gov/pubmed/24572742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2014.7 |
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