Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis

How environmental factors combine with genetic risk at the molecular level to promote complex trait diseases such as multiple sclerosis (MS) is largely unknown. In mice, N-glycan branching by the Golgi enzymes Mgat1 and/or Mgat5 prevents T cell hyperactivity, cytotoxic T-lymphocyte antigen 4 (CTLA-4...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Mkhikian, Haik, Grigorian, Ani, Li, Carey F., Chen, Hung-Lin, Newton, Barbara, Zhou, Raymond W., Beeton, Christine, Torossian, Sevan, Tatarian, Gevork Grikor, Lee, Sung-Uk, Lau, Ken, Walker, Erin, Siminovitch, Katherine A., Chandy, K. George, Yu, Zhaoxia, Dennis, James W., Demetriou, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133923/
https://ncbi.nlm.nih.gov/pubmed/21629267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1333
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi