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The mutation patterns in B-cell immunoglobulin receptors reflect the influence of selection acting at multiple time-scales
During the several-week course of an immune response, B cells undergo a process of clonal expansion, somatic hypermutation of the immunoglobulin (Ig) genes and affinity-dependent selection. Over a lifetime, each B cell may participate in multiple rounds of affinity maturation as part of different im...
Enregistré dans:
| Publié dans: | Philos Trans R Soc Lond B Biol Sci |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Royal Society
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4528419/ https://ncbi.nlm.nih.gov/pubmed/26194756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2014.0242 |
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