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The mutation patterns in B-cell immunoglobulin receptors reflect the influence of selection acting at multiple time-scales

During the several-week course of an immune response, B cells undergo a process of clonal expansion, somatic hypermutation of the immunoglobulin (Ig) genes and affinity-dependent selection. Over a lifetime, each B cell may participate in multiple rounds of affinity maturation as part of different im...

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Detalhes bibliográficos
Publicado no:Philos Trans R Soc Lond B Biol Sci
Main Authors: Yaari, Gur, Benichou, Jennifer I. C., Vander Heiden, Jason A., Kleinstein, Steven H., Louzoun, Yoram
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528419/
https://ncbi.nlm.nih.gov/pubmed/26194756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2014.0242
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