NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells

Sprouting blood vessels are led by filopodia-studded endothelial tip cells that respond to angiogenic signals. Mosaic lineage tracing previously revealed that NRP1 is essential for tip cell function, although its mechanistic role in tip cells remains poorly defined. Here, we show that NRP1 is dispen...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Fantin, Alessandro, Lampropoulou, Anastasia, Gestri, Gaia, Raimondi, Claudio, Senatore, Valentina, Zachary, Ian, Ruhrberg, Christiana
Format: Artigo
Language:Inglês
Published: Cell Press 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528263/
https://ncbi.nlm.nih.gov/pubmed/26051942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.05.018
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