Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor

The hypoxia-inducible factor (HIF) hydroxylases regulate hypoxia sensing in animals. In humans, they comprise three prolyl hydroxylases (PHD1–3 or EGLN1–3) and factor inhibiting HIF (FIH). FIH is an asparaginyl hydroxylase catalyzing post-translational modification of HIF-α, resulting in reduction o...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Tarhonskaya, Hanna, Hardy, Adam P., Howe, Emily A., Loik, Nikita D., Kramer, Holger B., McCullagh, James S. O., Schofield, Christopher J., Flashman, Emily
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2015
Предметы:
Enzymology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528135/
https://ncbi.nlm.nih.gov/pubmed/26112411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.653014
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