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Evidence for the Slow Reaction of Hypoxia-Inducible Factor Prolyl Hydroxylase 2 with Oxygen

The response of animals to hypoxia is mediated by the hypoxia-inducible transcription factor (HIF). Human HIF is regulated by four Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases: Prolyl hydroxylase domain enzymes (PHDs or EGLNs) 1–3 catalyse hydroxylation of two prolyl-residues in HIF, trigger...

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Detalhes bibliográficos
Main Authors: Flashman, Emily, Hoffart, Lee M., Hamed, Refaat B., Bollinger, J. Martin, Krebs, Carsten, Schofield, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160827/
https://ncbi.nlm.nih.gov/pubmed/20840591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2010.07804.x
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