Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor

The hypoxia-inducible factor (HIF) hydroxylases regulate hypoxia sensing in animals. In humans, they comprise three prolyl hydroxylases (PHD1–3 or EGLN1–3) and factor inhibiting HIF (FIH). FIH is an asparaginyl hydroxylase catalyzing post-translational modification of HIF-α, resulting in reduction o...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Tarhonskaya, Hanna, Hardy, Adam P., Howe, Emily A., Loik, Nikita D., Kramer, Holger B., McCullagh, James S. O., Schofield, Christopher J., Flashman, Emily
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2015
Onderwerpen:
Enzymology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528135/
https://ncbi.nlm.nih.gov/pubmed/26112411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.653014
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