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The inhibition of the GTPase activating protein-Ha-ras interaction by acidic lipids is due to physical association of the C-terminal domain of the GTPase activating protein with micellar structures.

The effects of fatty acids and phospholipids on the interaction of the full-length GTPase activating protein (GAP) as well as its isolated C-terminal domain and the Ha-ras proto-oncogene product p21 were studied by various methods, viz. GTPase activity measurements, fluorescence titrations and gel p...

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Библиографические подробности
Главные авторы: Serth, J, Lautwein, A, Frech, M, Wittinghofer, A, Pingoud, A
Формат: Artigo
Язык:Inglês
Опубликовано: 1991
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC452790/
https://ncbi.nlm.nih.gov/pubmed/2026138
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