Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity.

The GTPase-activating protein (GAP) stimulates the GTPase reaction of p21 by 5 orders of magnitude such that the kcat of the reaction is increased to 19 s-1. Mutations of residues in loop L1 (Gly-12 and Gly-13), in loop L2 (Thr-35 and Asp-38), and in loop L4 (Gln-61 and Glu-63) influence the reactio...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Gideon, P, John, J, Frech, M, Lautwein, A, Clark, R, Scheffler, J E, Wittinghofer, A
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364376/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1569940/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.5.2050
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