Long-term benefit of PD-L1 blockade in lung cancer associated with JAK3 activation

PD-1 immune checkpoint blockade occasionally results in durable clinical responses in advanced metastatic cancers. However, mechanism-based predictors of response to this immunotherapy remain incompletely characterized. We performed comprehensive genomic profiling on a tumor and germline sample from...

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Publicado no:Cancer Immunol Res
Main Authors: Van Allen, Eliezer M., Golay, Hadrien G., Liu, Yan, Koyama, Shohei, Wong, Karrie, Taylor-Weiner, Amaro, Giannakis, Marios, Harden, Maegan, Rojas-Rudilla, Vanesa, Chevalier, Aaron, Thai, Tran, Lydon, Christine, Mach, Stacy, Wong, Joshua A., Rabin, Alexandra R., Helmkamp, Joshua, Sholl, Lynette, Carter, Scott L., Oxnard, Geoffrey, Janne, Pasi, Getz, Gad, Lindeman, Neal, Hammerman, Peter S., Garraway, Levi A., Hodi, F. Stephen, Rodig, Scott, Dranoff, Glenn, Wong, Kwok-Kin, Barbie, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527885/
https://ncbi.nlm.nih.gov/pubmed/26014096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0024
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