Multigene predictors of tacrolimus exposure in kidney transplant recipients

AIM: Determine the effect of the genetic variants beyond CYP3A5*3 on tacrolimus disposition. PATIENTS & METHODS: We studied genetic correlates of tacrolimus trough concentrations with POR*28, CYP3A4*22 and ABCC2 haplotypes in a large, ethnically diverse kidney transplant cohort (n = 2008). RESUL...

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Detaylı Bibliyografya
Yayımlandı:Pharmacogenomics
Asıl Yazarlar: Pulk, Rebecca A, Schladt, David S, Oetting, William S, Guan, Weihua, Israni, Ajay K, Matas, Arthur J, Remmel, Rory P, Jacobson, Pamala A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Future Medicine Ltd 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527535/
https://ncbi.nlm.nih.gov/pubmed/26067485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs.15.42
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