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Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes

[Image: see text] Squalene (SQ) is an intermediate in the biosynthesis of sterols in eukaryotes and a few bacteria and of hopanoids in bacteria where they promote membrane stability and the formation of lipid rafts in their hosts. The genes for hopanoid biosynthesis are typically located on clusters...

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Detalhes bibliográficos
Publicado no:ACS Cent Sci
Main Authors: Pan, Jian-Jung, Solbiati, Jose O., Ramamoorthy, Gurusankar, Hillerich, Brandan S., Seidel, Ronald D., Cronan, John E., Almo, Steven C., Poulter, C. Dale
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527182/
https://ncbi.nlm.nih.gov/pubmed/26258173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.5b00115
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