RING dimerization links higher-order assembly of TRIM5α to synthesis of K63-linked polyubiquitin

Members of the tripartite motif (TRIM) protein family of RING E3 ubiquitin (Ub) ligases promote innate immune responses by catalyzing synthesis of polyubiquitin chains linked through lysine 63 (K63). Here we investigate the mechanism by which the TRIM5α retroviral restriction factor activates Ubc13,...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Yudina, Zinaida, Roa, Amanda, Johnson, Rory, Biris, Nikolaos, de Souza Aranha Vieira, Daniel A., Tsiperson, Vladislav, Reszka, Natalia, Taylor, Alexander B., Hart, P. John, Demeler, Borries, Diaz-Griffero, Felipe, Ivanov, Dmitri N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526822/
https://ncbi.nlm.nih.gov/pubmed/26212332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.072
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