Peripheral blood cells from children with RASopathies show enhanced spontaneous colonies growth in vitro and hyperactive RAS signaling

Germline mutations in genes coding for molecules involved in the RAS/RAF/MEK/ERK pathway are the hallmarks of a newly classified family of autosomal dominant syndromes termed RASopathies. Myeloproliferative disorders (MPDs), in particular, juvenile myelomonocytic leukemia, can lead to potentially se...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Blood Cancer J
मुख्य लेखकों: Gaipa, G, Bugarin, C, Cianci, P, Sarno, J, Bonaccorso, P, Biondi, A, Selicorni, A
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group 2015
विषय:
Original Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526778/
https://ncbi.nlm.nih.gov/pubmed/26186557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2015.52
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