Peripheral blood cells from children with RASopathies show enhanced spontaneous colonies growth in vitro and hyperactive RAS signaling

Germline mutations in genes coding for molecules involved in the RAS/RAF/MEK/ERK pathway are the hallmarks of a newly classified family of autosomal dominant syndromes termed RASopathies. Myeloproliferative disorders (MPDs), in particular, juvenile myelomonocytic leukemia, can lead to potentially se...

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Detalhes bibliográficos
Publicado no:Blood Cancer J
Main Authors: Gaipa, G, Bugarin, C, Cianci, P, Sarno, J, Bonaccorso, P, Biondi, A, Selicorni, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526778/
https://ncbi.nlm.nih.gov/pubmed/26186557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2015.52
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