Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation

The central region of MDM2 is critical for p53 activation and tumor suppression. Upon ribosomal stress, this region is bound by ribosomal proteins, particularly ribosomal protein L11 (RPL11), leading to MDM2 inactivation and subsequent p53 activation. Here, we solved the complex structure of human M...

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書目詳細資料
發表在:Genes Dev
Main Authors: Zheng, Jiangge, Lang, Yue, Zhang, Qi, Cui, Di, Sun, Haili, Jiang, Lun, Chen, Zhenhang, Zhang, Rui, Gao, Yina, Tian, Wenli, Wu, Wei, Tang, Jun, Chen, Zhongzhou
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2015
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526736/
https://ncbi.nlm.nih.gov/pubmed/26220995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.261792.115
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