Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation

The central region of MDM2 is critical for p53 activation and tumor suppression. Upon ribosomal stress, this region is bound by ribosomal proteins, particularly ribosomal protein L11 (RPL11), leading to MDM2 inactivation and subsequent p53 activation. Here, we solved the complex structure of human M...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Zheng, Jiangge, Lang, Yue, Zhang, Qi, Cui, Di, Sun, Haili, Jiang, Lun, Chen, Zhenhang, Zhang, Rui, Gao, Yina, Tian, Wenli, Wu, Wei, Tang, Jun, Chen, Zhongzhou
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526736/
https://ncbi.nlm.nih.gov/pubmed/26220995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.261792.115
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