GRWD1 negatively regulates p53 via the RPL11–MDM2 pathway and promotes tumorigenesis

The ribosomal protein L11 (RPL11) binds and inhibits the MDM2 ubiquitin ligase, thereby promoting p53 stability. Thus, RPL11 acts as a tumor suppressor. Here, we show that GRWD1 (glutamate‐rich WD40 repeat containing 1) physically and functionally interacts with RPL11. GRWD1 is localized to nucleoli...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Kayama, Kota, Watanabe, Shinya, Takafuji, Takuya, Tsuji, Takahiro, Hironaka, Kensuke, Matsumoto, Masaki, Nakayama, Keiichi I, Enari, Masato, Kohno, Takashi, Shiraishi, Kouya, Kiyono, Tohru, Yoshida, Kazumasa, Sugimoto, Nozomi, Fujita, Masatoshi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5210153/
https://ncbi.nlm.nih.gov/pubmed/27856536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201642444
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