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GRWD1 negatively regulates p53 via the RPL11–MDM2 pathway and promotes tumorigenesis
The ribosomal protein L11 (RPL11) binds and inhibits the MDM2 ubiquitin ligase, thereby promoting p53 stability. Thus, RPL11 acts as a tumor suppressor. Here, we show that GRWD1 (glutamate‐rich WD40 repeat containing 1) physically and functionally interacts with RPL11. GRWD1 is localized to nucleoli...
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| Publicado no: | EMBO Rep |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5210153/ https://ncbi.nlm.nih.gov/pubmed/27856536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201642444 |
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