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Let-7 Represses Carcinogenesis and a Stem Cell Phenotype in the Intestine via Regulation of Hmga2

Let-7 miRNAs comprise one of the largest and most highly expressed family of miRNAs among vertebrates, and is critical for promoting differentiation, regulating metabolism, inhibiting cellular proliferation, and repressing carcinogenesis in a variety of tissues. The large size of the Let-7 family of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:PLoS Genet
Hauptverfasser: Madison, Blair B., Jeganathan, Arjun N., Mizuno, Rei, Winslow, Monte M., Castells, Antoni, Cuatrecasas, Miriam, Rustgi, Anil K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526516/
https://ncbi.nlm.nih.gov/pubmed/26244988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005408
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