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The tumor suppressor microRNA let-7 represses the HMGA2 oncogene

HMGA2, a high-mobility group protein, is oncogenic in a variety of tumors, including benign mesenchymal tumors and lung cancers. Knockdown of Dicer in HeLa cells revealed that the HMGA2 gene is transcriptionally active, but its mRNA is destabilized in the cytoplasm through the microRNA (miRNA) pathw...

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Autores principales: Lee, Yong Sun, Dutta, Anindya
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855228/
https://ncbi.nlm.nih.gov/pubmed/17437991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1540407
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