Serine 350 of Human Pregnane X Receptor Is Crucial for Its Heterodimerization with Retinoid X Receptor Alpha and Transactivation of Target Genes in Vitro and in Vivo

The human pregnane X receptor (hPXR), a member of the nuclear receptor superfamily, senses xenobiotics and controls the transcription of genes encoding drug-metabolizing enzymes and transporters. The regulation of hPXR’s transcriptional activation of its target genes is important for xenobiotic deto...

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Vydáno v:Biochem Pharmacol
Hlavní autoři: Wang, Yue-Ming, Chai, Sergio C., Lin, Wenwei, Chai, Xiaojuan, Elias, Ayesha, Wu, Jing, Ong, Su Sien, Pondugula, Satyanarayana R., Beard, Jordan A., Schuetz, Erin G., Zeng, Su, Xie, Wen, Chen, Taosheng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526351/
https://ncbi.nlm.nih.gov/pubmed/26119819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.06.018
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