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Dynamic Allostery of the Catabolite Activator Protein Revealed by Interatomic Forces
The Catabolite Activator Protein (CAP) is a showcase example for entropic allostery. For full activation and DNA binding, the homodimeric protein requires the binding of two cyclic AMP (cAMP) molecules in an anti-cooperative manner, the source of which appears to be largely of entropic nature accord...
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| Publicat a: | PLoS Comput Biol |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4526232/ https://ncbi.nlm.nih.gov/pubmed/26244893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004358 |
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