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A combined optogenetic-knockdown strategy reveals a major role of tomosyn in mossy fiber synaptic plasticity

Neurotransmitter release probability (P(r)) largely determines the dynamic properties of synapses. While much is known on the role of presynaptic proteins in transmitter release, their specific contribution to synaptic plasticity is unclear. One such protein, tomosyn, is believed to reduce P(r) by i...

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Publicado en:Cell Rep
Autores principales: Ben-Simon, Yoav, Rodenas-Ruano, Alma, Alviña, Karina, Lam, Alice D., Stuenkel, Edward L., Castillo, Pablo E., Ashery, Uri
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525481/
https://ncbi.nlm.nih.gov/pubmed/26166572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.037
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