XRCC4/XLF Interaction Is Variably Required for DNA Repair and Is Not Required for Ligase IV Stimulation

The classic nonhomologous end-joining (c-NHEJ) pathway is largely responsible for repairing double-strand breaks (DSBs) in mammalian cells. XLF stimulates the XRCC4/DNA ligase IV complex by an unknown mechanism. XLF interacts with XRCC4 to form filaments of alternating XRCC4 and XLF dimers that brid...

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Published in:Mol Cell Biol
Main Authors: Roy, Sunetra, de Melo, Abinadabe J., Xu, Yao, Tadi, Satish K., Négrel, Aurélie, Hendrickson, Eric, Modesti, Mauro, Meek, Katheryn
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525314/
https://ncbi.nlm.nih.gov/pubmed/26100018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01503-14
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