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Repression of CD24 surface protein expression by oncogenic Ras is relieved by inhibition of Raf but not MEK or PI3K

CD24 is a dynamically regulated cell surface protein. High expression of CD24 leads to progression of lung, prostrate, colon, and pancreatic cancers, among others. In contrast, low expression of CD24 leads to cell proliferation and metastasis of breast cancer stem cells (BCSCs). Activating mutations...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Pallegar, Nikitha K., Ayre, D. Craig, Christian, Sherri L.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525067/
https://ncbi.nlm.nih.gov/pubmed/26301220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2015.00047
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