Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2

Exacerbated mRNA translation during brain development has been linked to autism spectrum disorders (ASDs). Deletion of the eukaryotic initiation factor 4E (eIF4E)-binding protein 2 gene (Eif4ebp2), encoding the suppressor of mRNA translation initiation 4E-BP2, leads to an imbalance in excitatory-to-...

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Publicado en:J Neurosci
Autores principales: Aguilar-Valles, Argel, Matta-Camacho, Edna, Khoutorsky, Arkady, Gkogkas, Christos, Nader, Karim, Lacaille, Jean-Claude, Sonenberg, Nahum
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2015
Materias:
Brief Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524980/
https://ncbi.nlm.nih.gov/pubmed/26245973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4615-14.2015
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