Repression of intestinal stem cell function and tumorigenesis through direct phosphorylation of β-catenin and Yap by PKCζ

Intestinal epithelial homeostasis requires continuous renewal supported by stem cells located in the base of the crypt. Disruption of this balance results in failure to regenerate and initiates tumorigenesis. The β-catenin and Yap pathways in Lgr5(+) stem cells have been shown to be central to this...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Llado, Victoria, Nakanishi, Yuki, Duran, Angeles, Reina-Campos, Miguel, Shelton, Phillip M., Linares, Juan F., Yajima, Tomoko, Campos, Alex, Aza-Blanc, Pedro, Leitges, Michael, Diaz-Meco, Maria T., Moscat, Jorge
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524805/
https://ncbi.nlm.nih.gov/pubmed/25660024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.01.007
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