Repression of intestinal stem cell function and tumorigenesis through direct phosphorylation of β-catenin and Yap by PKCζ

Intestinal epithelial homeostasis requires continuous renewal supported by stem cells located in the base of the crypt. Disruption of this balance results in failure to regenerate and initiates tumorigenesis. The β-catenin and Yap pathways in Lgr5(+) stem cells have been shown to be central to this...

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Pubblicato in:Cell Rep
Autori principali: Llado, Victoria, Nakanishi, Yuki, Duran, Angeles, Reina-Campos, Miguel, Shelton, Phillip M., Linares, Juan F., Yajima, Tomoko, Campos, Alex, Aza-Blanc, Pedro, Leitges, Michael, Diaz-Meco, Maria T., Moscat, Jorge
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524805/
https://ncbi.nlm.nih.gov/pubmed/25660024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.01.007
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