c-Myc phosphorylation by PKCζ represses prostate tumorigenesis

Studies showing reduced PKCζ expression or enzymatic activity in different types of human cancers support the clinical relevance of PKCζ as a tumor suppressor. However, the in vivo role of PKCζ and its mechanisms of action in prostate cancer remain unclear. Here we demonstrate that the genetic inact...

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Autori principali: Kim, Ji Young, Valencia, Tania, Abu-Baker, Shadi, Linares, Juan, Lee, Sang Jun, Yajima, Tomoko, Chen, Jing, Eroshkin, Alexey, Castilla, Elias A., Brill, Laurence M., Medvedovic, Mario, Leitges, Michael, Moscat, Jorge, Diaz-Meco, Maria T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631641/
https://ncbi.nlm.nih.gov/pubmed/23550155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221799110
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