Synthesis and Biological Characterization of a Promising F-18 PET Tracer for Vesicular Acetylcholine Transporter

Nine fluorine-containing vesicular acetylcholine transporter (VAChT) inhibitors were synthesized and screened as potential PET tracers for imaging the VAChT. Compound 18a was one of the most promising carbonyl-containing benzovesamicol analogues; the minus enantiomer, (-)-18a displayed high potency...

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Publicat a:Bioorg Med Chem
Autors principals: Tu, Zhude, Zhang, Xiang, Jin, Hongjun, Yue, Xuyi, Padakanti, Prashanth K., Yu, Lihai, Liu, Hui, Flores, Hubert P., Kaneshige, Kota, Parsons, Stanley M., Perlmutter, Joel S.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524497/
https://ncbi.nlm.nih.gov/pubmed/26138195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.05.058
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