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Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis

BACKGROUND: The dioxin (AhR) receptor can have oncogenic or tumor suppressor activities depending on the phenotype of the target cell. We have shown that AhR knockdown promotes melanoma primary tumorigenesis and lung metastasis in the mouse and that human metastatic melanomas had reduced AhR levels...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Cancer
Hauptverfasser: Contador-Troca, María, Alvarez-Barrientos, Alberto, Merino, Jaime M., Morales-Hernández, Antonio, Rodríguez, María I., Rey-Barroso, Javier, Barrasa, Eva, Cerezo-Guisado, María I., Catalina-Fernández, Inmaculada, Sáenz-Santamaría, Javier, Oliver, Francisco J., Fernandez-Salguero, Pedro M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524442/
https://ncbi.nlm.nih.gov/pubmed/26242870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0419-9
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