Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis

BACKGROUND: The dioxin (AhR) receptor can have oncogenic or tumor suppressor activities depending on the phenotype of the target cell. We have shown that AhR knockdown promotes melanoma primary tumorigenesis and lung metastasis in the mouse and that human metastatic melanomas had reduced AhR levels...

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Bibliografski detalji
Izdano u:Mol Cancer
Glavni autori: Contador-Troca, María, Alvarez-Barrientos, Alberto, Merino, Jaime M., Morales-Hernández, Antonio, Rodríguez, María I., Rey-Barroso, Javier, Barrasa, Eva, Cerezo-Guisado, María I., Catalina-Fernández, Inmaculada, Sáenz-Santamaría, Javier, Oliver, Francisco J., Fernandez-Salguero, Pedro M.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524442/
https://ncbi.nlm.nih.gov/pubmed/26242870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0419-9
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