Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis

BACKGROUND: The dioxin (AhR) receptor can have oncogenic or tumor suppressor activities depending on the phenotype of the target cell. We have shown that AhR knockdown promotes melanoma primary tumorigenesis and lung metastasis in the mouse and that human metastatic melanomas had reduced AhR levels...

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Gepubliceerd in:Mol Cancer
Hoofdauteurs: Contador-Troca, María, Alvarez-Barrientos, Alberto, Merino, Jaime M., Morales-Hernández, Antonio, Rodríguez, María I., Rey-Barroso, Javier, Barrasa, Eva, Cerezo-Guisado, María I., Catalina-Fernández, Inmaculada, Sáenz-Santamaría, Javier, Oliver, Francisco J., Fernandez-Salguero, Pedro M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524442/
https://ncbi.nlm.nih.gov/pubmed/26242870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0419-9
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