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Structural Determinants for the Selective Anti-HIV-1 Activity of the All-β Alternative Conformer of XCL1

HIV-1 replication is regulated in vivo by a complex network of cytokines and chemokines. XCL1/lymphotactin, a unique metamorphic chemokine, was recently identified as a broad-spectrum endogenous HIV-1 inhibitor that blocks viral entry via direct interaction with the gp120 envelope glycoprotein. HIV-...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Guzzo, Christina, Fox, Jamie C., Miao, Huiyi, Volkman, Brian F., Lusso, Paolo
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524057/
https://ncbi.nlm.nih.gov/pubmed/26085164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01285-15
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