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Examination of Glycosaminoglycan Binding Sites on the XCL1 Dimer

Known for its distinct metamorphic behavior, XCL1 interconverts between a canonical chemokine folded monomer (XCL1(mon)) that interacts with the receptor, XCR1, and a unique dimer (XCL1(dim)) that interacts with glycosaminoglycans and inhibits HIV-1 activity. This study presents the first detailed a...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Fox, Jamie C., Tyler, Robert C., Peterson, Francis C., Dyer, Douglas P., Zhang, Fuming, Linhardt, Robert J., Handel, Tracy M., Volkman, Brian F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775286/
https://ncbi.nlm.nih.gov/pubmed/26836755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01329
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